ChloroquineV1, Main, Exploration, bibRecord, 001764

Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach

Identifieur interne : 001764 ( Main/Exploration ); précédent : 001763; suivant : 001765

Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach

Auteurs : Faustine Dubar [France] ; G. Anquetin [France] ; Bruno Pradines [France] ; Daniel Dive [France] ; Jamal Khalife [France] ; Christophe Biot [France]

Source :

Journal of Medicinal Chemistry [ 0022-2623 ] ; 2009-12-24.

RBID : Hal:hal-00641967

Abstract

The derivatization of the fluoroquinolone ciprofloxacin greatly increases its antimalarial activity by combining bioorganometallic chemistry and the prodrug approach. Two new achiral compounds 2 and 4 were found to be 10- to 100-fold more active than ciprofloxacin against Plasmodium falciparum chloroquinesusceptible and chloroquine-resistant strains. These achiral derivatives killed parasites more rapidly than did ciprofloxacin. Compounds 2 and 4 were revealed to be promising leads, creating a new family of antimalarial agents.

Url:

https://hal.archives-ouvertes.fr/hal-00641967

DOI: 10.1021/jm901357n

Affiliations:

France

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000086
to stream Hal, to step Curation: 000086
to stream Hal, to step Checkpoint: 000192
to stream Main, to step Merge: 001768
to stream Main, to step Curation: 001764

Le document en format XML

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          <orgName>Université de Lille</orgName>
          <date type="start">2018-01-01</date>
          <desc>            <address>              <addrLine>Lille</addrLine>
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          <date type="start">1939-10-19</date>
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<country>France</country>
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</analytic>
<idno type="DOI">10.1021/jm901357n</idno>
<series><title level="j">Journal of Medicinal Chemistry</title>
<idno type="ISSN">0022-2623</idno>
<imprint><date type="datePub">2009-12-24</date>
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<front><div type="abstract" xml:lang="en">              <p>The derivatization of the fluoroquinolone ciprofloxacin greatly increases its antimalarial activity by combining bioorganometallic chemistry and the prodrug approach. Two new achiral compounds 2 and 4 were found to be 10- to 100-fold more active than ciprofloxacin against Plasmodium falciparum chloroquinesusceptible and chloroquine-resistant strains. These achiral derivatives killed parasites more rapidly than did ciprofloxacin. Compounds 2 and 4 were revealed to be promising leads, creating a new family of antimalarial agents.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
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</noRegion>
<name sortKey="Anquetin, G" sort="Anquetin, G" uniqKey="Anquetin G" first="G." last="Anquetin">G. Anquetin</name>
<name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
<name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
<name sortKey="Pradines, Bruno" sort="Pradines, Bruno" uniqKey="Pradines B" first="Bruno" last="Pradines">Bruno Pradines</name>
</country>
</tree>
</affiliations>
</record>

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Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach

Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach

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